Since 1987 the archaeological site at Amphipolis has had its own museum, displaying the wealth of material from the excavations begun by archaeologist Dimitris Lazaridis. Curator of Eastern Macedonian Antiquities and General Inspector of Antiquities, he carried out the bulk of excavations at Amphipolis from 1956 to 1984. Construction work on the museum building began in 1976 and was completed in 1987, to plans by architect A. Bakirtzis.

The exhibition presents the history of the ancient city and its environs both by subject matter and chronologically.  Finds from the mouth of the Strymon River testify to human presence and activity from the Mesolithic to the Early Iron Age (5000 BC-750 BC). Attic and Corinthian vases from archaic tombs testify to the gradual penetration of Greek populations into Thrace, and the founding of Greek cities by the mouth of the Strymon as early as the mid-7th century BC; numerous other finds show public and private life in Amphipolis during Classical and Hellenistic times, and the town’s prominence under Roman rule. The Early Christian and Byzantine exhibits are similarly representative, though they point to the gradual decline of Amphipolis in that period. The museum rooms also offer interesting information on the area’s modern history, as well as chronicling archaeological research conducted there.